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Let $A$ be the set of all integers not of the form $p+2^{k}+2^l$ (where $k,l\geq 0$ and $p$ is prime). Is the upper density of $A$ positive?
Crocker [Cr71] has proved there are are $\gg\log\log N$ such integers in $\{1,\ldots,N\}$ (any number of the form $2^{2^m}-1$ with $m\geq 3$ suffices). Pan [Pa11] improved this to $\gg_\epsilon N^{1-\epsilon}$ for any $\epsilon>0$. Erdős believes this cannot be proved by covering systems, i.e. integers of the form $p+2^k+2^l$ exist in every infinite arithmetic progression.

See also [10], [11], and [16].