In other words, this problem asks to determine the chromatic number of the Kneser graph. This would be best possible: if $n=kr-1+(t-1)(k-1)$ then decomposing $[n]$ as one set $X_1$ of size $kr-1$ and $t-1$ sets $X_2,\ldots,X_{t}$ of size $k-1$, a colouring without $k$ pairwise disjoint edges is given colouring all subsets of $X_0$ in colour $1$ and assigning an edge with colour $2\leq i\leq t$ if $i$ is minimal such that $X_i$ intersects the edge.

When $k=2$ this was conjectured by Kneser and proved by Lovász [Lo78]. The general case was proved by Alon, Frankl, and Lovász [AFL86].