Hough and Nielsen [HoNi19] proved that at least one modulus must be divisible by either $2$ or $3$. A simpler proof of this fact was provided by Balister, Bollobás, Morris, Sahasrabudhe, and Tiba [BBMST22].
Selfridge has shown (as reported in [Sc67]) that such a covering system exists if a covering system exists with moduli $n_1,\ldots,n_k$ such that no $n_i$ divides any other $n_j$ (but the latter has been shown not to exist, see [586]).