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Suppose $A\subseteq \{1,\ldots,N\}$ is such that there are no $k+1$ elements of $A$ which are relatively prime. An example is the set of all multiples of the first $k$ primes. Is this the largest such set?
This was disproved for $k=212$ by Ahlswede and Khachatrian [AhKh94], who suggest that their methods can disprove this for arbitrarily large $k$.

Erdős later asked [Er95] if the conjecture remains true provided $N\geq (1+o(1))p_k^2$ (or, in a weaker form, whether it is true for $N$ sufficiently large depending on $k$).

Additional thanks to: Zachary Chase