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Is it true that, for any $\delta>1/2$, if $N$ is sufficiently large and $A\subseteq \{1,\ldots,N\}$ has $\lvert A\rvert \geq \delta N$ then there exist $a,b,c\in A$ such that \[\frac{1}{a}=\frac{1}{b}+\frac{1}{c}.\]
The colouring version of this is [303], which was solved by Brown and Rödl [BrRo91].

The possible alternative question, that if $A\subseteq \mathbb{N}$ is a set of positive lower density then must there exist $a,b,c\in A$ such that \[\frac{1}{a}=\frac{1}{b}+\frac{1}{c},\] has a negative answer, taking for example $A$ to be the union of $[5^k,(1+\epsilon)5^k]$ for large $k$ and sufficiently small $\epsilon>0$. This was observed by Hunter and Sawhney.

Additional thanks to: Zachary Hunter and Mehtaab Sawhney