The weaker conjecture that there exists some $c>0$ such that $(2-c)\Delta^2$ sets suffice was proved by Molloy and Reed [MoRe97], who proved that $1.998\Delta^2$ sets suffice (for $\Delta$ sufficiently large). This was improved to $1.93\Delta^2$ by Bruhn and Joos [BrJo18] and to $1.835\Delta^2$ by Bonamy, Perrett, and Postle [BPP22]. The best bound currently available is \[1.772\Delta^2,\] proved by Hurley, de Joannis de Verclos, and Kang [HJK22].
Erdős and Nešetřil also asked the easier problem of whether $G$ containing at least $\tfrac{5}{4}\Delta^2$ many edges implies $G$ containing two strongly independent edges. This was proved independently by Chung-Trotter and Gyárfás-Tuza.